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CAS RN: 123663-49-0 | Product Number: I0945
Iguratimod
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Purity: >98.0%(T)(HPLC)
Synonyms:
- N-(3-Formamido-4-oxo-6-phenoxy-4H-chromen-7-yl)methanesulfonamide
- N-[7-(Methanesulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl]formamide
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹3,500.00
|
1 | 14 |
|
| 250MG |
₹10,400.00
|
2 | ≥40 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | I0945 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__4N__2O__6S = 374.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| Packaging and Container
|
25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 123663-49-0 |
| Reaxys Registry Number | 8640145 |
| PubChem Substance ID | 253660421 |
| MDL Number | MFCD00882374 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 238.0 to 242.0 °C |
Properties (reference)
| Melting Point | 240 °C |
| Solubility in water | Insoluble |
| Solubility (insoluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
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Transport Information:
Application
Iguratimod (T-614): An Agent with Anti-Inflammatory and Immunomodulatory Activities
Iguratimod (T-614) is an agent with anti-inflammatory and immunomodulatory activities. Iguratimod inhibits the production of immune globulin and inflammatory cytokines such as TNF-α, IL-1β and IL-6 in vitro. Even though the mechanism of action of iguratimod is still not fully understood, the suppression of nuclear factor kappa B (NF-κB) activation has been indicated. Iguratimod is used as a disease modifying anti-rheumatic drug (DMARD). (The product is for research purpose only.)
References
- Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one. 1st Communication: antiinflammatory, analgesic and other related properties
- K. Tanaka, T. Shimotori, S. Makino, Y. Aikawa, T. Inaba, C. Yoshida, S. Takano, Arzneim.-Forsch. 1992, 42, 935.
- Synthesis and antiinflammatory activity of 7-methanesulfonylamino-6-phenoxychromones. Antiarthritic effect of the 3-formylamino compound (T-614) in chronic inflammatory disease models
- An anti-rheumatic agent T-614 inhibits NF-κB activation in LPS- and TNF-α-stimulated THP-1 cells without interfering with IκBα degradation
- Inhibitory effects of an anti-rheumatic agent T-614 on immunoglobulin production by cultured B cells and rheumatoid synovial tissues engrafted into SCID mice
- Determination of iguratimod in rat plasma by high performance liquid chromatography: method and application
PubMed Literature
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Specifications
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