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CAS RN: 1225451-84-2 | Product Number: K0060
SKLB1002
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Purity: >98.0%(HPLC)
Synonyms:
- 6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]quinazoline
- 2-[(6,7-Dimethoxyquinazolin-4-yl)thio]-5-methyl-1,3,4-thiadiazole
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹4,400.00
|
Contact Us | ≥40 |
|
| 100MG |
₹7,800.00
|
Contact Us | 27 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | K0060 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__2N__4O__2S__2 = 320.39 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 1225451-84-2 |
| Reaxys Registry Number | 24520489 |
| PubChem Substance ID | 354335818 |
| MDL Number | MFCD27938707 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 191.0 to 195.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 193 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
Application
SKLB1002: A Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Inhibitor
SKLB1002 has been reported as a vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor, as an efficient anti-angiogenesis agent. Experimental evidence demonstrated VEGFR has been associated with tumor angiogenesis, thus making it a valuable and attractive target for drug design for therapeutic applications.
References
- SKLB1002, a Novel Potent Inhibitor of VEGF Receptor 2 Signaling, Inhibits Angiogenesis and Tumor Growth In Vivo
- SKLB1002, a novel inhibitor of VEGF receptor 2 signaling, induces vascular normalization to improve systemically administered chemotherapy efficacy
- Synergic antitumor effect of SKLB1002 and local hyperthermia in 4T1 and CT26
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Specifications
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