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CAS RN: 82034-46-6 | Product Number: L0327
Loteprednol Etabonate
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Purity: >98.0%(HPLC)
Synonyms:
- HGP 1
- P 5604
- CDDD 5604
- Chloromethyl (11β,17α)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate
- (11β,17α)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic Acid Chloromethyl Ester
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
₹6,900.00
|
3 | 13 |
|
| 250MG |
₹13,200.00
|
4 | 27 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | L0327 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__3__1ClO__7 = 466.96 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 82034-46-6 |
| Reaxys Registry Number | 5461012 |
| PubChem Substance ID | 468592150 |
| MDL Number | MFCD00870765 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +38.0 to +42.0 deg(C=1, dioxane) |
Properties (reference)
| Melting Point | 225 °C(dec.) |
| Specific Rotation | 40° (C=1,Dioxane) |
| Maximum Absorption Wavelength | 244 nm |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.0005 g/l 25 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
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Application
Loteprednol Etabonate: A “Soft” Corticosteroid
Loteprednol etabonate is a classed as a “soft” corticosteroid designed based on the “inactive metabolite approach”. It is locally metabolized by hydrolysis to the corresponding inactive cortienic acid derivative, and thus limiting or eliminating the associated systemic and local side effects. Corticosteroids play a role in cellular signaling, immune function, inflammation and protein regulation, and they are commonly used to control inflammation. However, there is no generally accepted explanation for the mechanism of action of corticosteroids. Loteprednol etabonate is used to treat inflammations of the eye in clinical. (The product is for research purpose only.)
References
- Soft drugs--10. Blanching activity and receptor binding affinity of a new type of glucocorticoid: loteprednol etabonate
- Metabolism, distribution, and transdermal permeation of a soft corticosteroid, loteprednol etabonate
- Ocular absorption and distribution of loteprednol etabonate, a soft steroid, in rabbit eyes
- Soft steroids: a new approach to the treatment of inflammatory airways diseases (a review)
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