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CAS RN: 128794-94-5 | Product Number: M2387

Mycophenolate Mofetil

Purity: >98.0%(T)(HPLC)

Synonyms:

2-(4-Morpholinyl)ethyl (E)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate
(E)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid 2-(4-Morpholinyl)ethyl Ester

Product Documents:

Size	Unit Price	Hyderabad	Japan*	Quantity
100MG	₹2,000.00	Contact Us	14
1G	₹5,700.00	4	≥100

*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

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General Information plus

Specifications & Properties plus

Specifications

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %
Melting point	94.0 to 98.0 °C

Properties (reference)

Melting Point	96 °C
Solubility in water	Insoluble
Degree of solubility in water	43 mg/l
Solubility (soluble in)	Methanol

Safety & Regulations plus

GHS

Pictogram
Signal Word	Danger
Hazard Statements	H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H351 : Suspected of causing cancer.
Precautionary Statements	P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up.

Related Laws:

RTECS#

MP7746700

Transport Information:

Applications & Literature plus

Application

Mycophenolate mofetil (MMF): An Inhibitor of Inosine Monophosphate Dehydrogenase (IMPDH), Needed for the Growth of T Cells and B Cells

Mycophenolate mofetil (abbrev: MMF) is an ester prodrug of the active immunosuppressant mycophenolic acid (MPA)[M2216] . MPA is a noncompetitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), an important enzyme in the de novo synthesis of guanosine nucleotides in T and B lymphocytes. MMF is a widely used component of immunosuppressive regimens in organ transplantation. (The product is for research purpose only.)

References

Mycophenolate mofetil: A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in renal transplantation
- B. Fulton, A. Markham, Drugs 1996, 51, 278.
Mycophenolate mofetil (a review)
- J. J. Lipsky, Lancet 1996, 348, 1357.
Mycophenolate mofetil and its mechanisms of action (a review)
- A. C. Allison, E. M. Eugui, Immunopharmacology 2000, 47, 85.
Regulatory T cells induced by 1α,25-dihydroxyvitamin D₃ and mycophenolate mofetil treatment mediate transplantation tolerance
- S. Gregori, M. Casorati, S. Amuchastegui, S. Smiroldo, A. M. Davalli, L. Adorini, J. Immunol. 2001, 167, 1945.
Mycophenolate mofetil in organ transplantation: focus on metabolism, safety and tolerability (a review)
- M. Shipkova, V. W. Armstrong, M. Oellerich, E. Wieland, Expert Opin. Drug Metab. Toxicol. 2005, 1, 505.

PubMed Literature

Documents

Immunosuppressants and Immunostimulants for Research and Experimental Use

Immune System, Inflammation, Allergy Research Reagents

Pharmaceutical Ingredients for Research and Experimental Use

Pharmacologically Active Metabolites

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Product Categories

Chemicals by Class

6-Membered Heterocyclic Compounds [Chemical Structural Class]

Morpholines [Chemical Structural Class]

Life Science

Chemicals by Class

6-Membered Heterocyclic Compounds [Chemical Structural Class]

Morpholines [Chemical Structural Class]

Product Number	M2387
Purity / Analysis Method	>98.0%(T)(HPLC)
Molecular Formula / Molecular Weight	C__2__3H__3__1NO__7 = 433.50
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
Packaging and Container	1G-Glass Bottle with Plastic Insert (View image)
CAS RN	128794-94-5
Reaxys Registry Number	14419508
PubChem Substance ID	253661600
Merck Index (14)	6327
MDL Number	MFCD00867568

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CAS RN: 128794-94-5 | Product Number: M2387