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CAS RN: 105816-04-4 | Product Number: N0912
Nateglinide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- N-[(trans-4-Isopropylcyclohexyl)carbonyl]-D-phenylalanine
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 500MG |
₹5,500.00
|
3 | 22 |
|
| 1G |
₹6,800.00
|
Contact Us | 17 |
|
| 5G |
₹16,200.00
|
3 | 5 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | N0912 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__7NO__3 = 317.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 105816-04-4 |
| Reaxys Registry Number | 6486870 |
| PubChem Substance ID | 160871031 |
| Merck Index (14) | 6428 |
| MDL Number | MFCD00875706 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -36.5 to -40.0 deg(C=1, 0.1mol/L NaOH) |
Properties (reference)
| Specific Rotation | -38° (C=1,0.1mol/L NaHO sol.) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.0066 g/l |
GHS
Related Laws:
| RTECS# | SQ7318950 |
Transport Information:
Application
速効性のATP感受性K+チャンネルアンタゴニスト，ナテグリニド
Nateglinide is a D-phenylalanine derivative which rapidly increases the release of insulin from pancreatic B-cells. More rapidly than that of sulfonylurea antidiabetics, nateglinide inhibits ATP-gated K+ channels and thereby causes depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. (The product is for research purpose only.)
References
- Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent, (－)-N-(trans-4-isopropylcyclohexane-carbonyl)-D-phenylalanine (A-4166)
- The effect of food on the oral bioavailability and the pharmacodynamic actions of the insulinotropic agent nateglinide in healthy subjects
- Pancreatic β-cell KATP channel activity and membrane-binding studies with nateglinide: a comparison with sulfonylureas and repaglinide
- Nateglinide (a review)
- Nateglinide quantification in rabbit plasma by HPLC: Optimization and application to pharmacokinetic study
- Development and validation of a stereoselective HPLC method for the determination of the in vitro transport of nateglinide enantiomers in rat intestine
PubMed Literature
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