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Published TCIMAIL newest issue No.200 | Product Document Searching Made Easy by 2D Code! | [TCIPracticalExample] Suzuki-Miyaura Coupling Using Encapsulated...

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CAS RN: 82419-36-1 | Product Number: O0403

Ofloxacin

Purity: >98.0%(T)(HPLC)

Synonyms:

9-Fluoro-3,7-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic Acid

Product Documents:

Size	Unit Price	Hyderabad	Japan*	Quantity
5G	₹8,800.00	3	26
25G	₹12,800.00	2	1

*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

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General Information plus

Specifications & Properties plus

Specifications

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Neutralization titration)	min. 98.0 %

Properties (reference)

Melting Point	263 °C
Maximum Absorption Wavelength	326 nm (H__2O)

Safety & Regulations plus

GHS

Related Laws:

RTECS#

UU8815500

Transport Information:

Applications & Literature plus

Application

Ofloxacin: A Synthetic Fluoroquinolone Antimicrobial, Ofloxacin

Ofloxacin is a synthetic fluoroquinolone antimicrobial structurally related to nalidixic acid [N0490]. Ofloxacin has broad-spectrum bactericidal activity against most Gram-negative bacteria, many Gram-positive bacteria and some anaerobes. The mechanism of action of ofloxacin (and other fluoroquinolone) involves inhibition of bacterial topoisomerase IV and DNA gyrase (topoisomerases II), enzymes required for DNA replication, transcription, repair and recombination. The active S-(-)-enantiomer of ofloxacin is levofloxacin [L0193]. (The product is for research purpose only.)

References

Ofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use
- J. P. Monk, D. M. Campoli-Richards, Drugs 1987, 33, 346.
Quinolones in 2005: an update (a review)
- F. Van Bambeke, J.-M. Michot, J. Van Eldere, P. M. Tulkens, Clin. Microbiol. Infect. 2005, 11, 256.
Moxifloxacin [M2479], ofloxacin, sparfloxacin [S0896], and ciprofloxacin [C2227, C2510] against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy
- R. K. Shandil, R. Jayaram, P. Kaur, S. Gaonkar, B. L. Suresh, B. N. Mahesh, R. Jayashree, V. Nandi, S. Bharath, V. Balasubramanian, Antimicrob. Agents Chemother. 2007, 51j, 576.
Synthesis and antibacterial activities of optically active ofloxacin
- I. Hayakawa, S. Atarashi, S. Yokohama, M. Imamura, K. Sakano, M. Furukawa, Antimicrob. Agents Chemother. 1986, 29, 163.
Direct determination of four fluoroquinolones, enoxacin [E0762], norfloxacin [N0817], ofloxacin, and ciprofloxacin [C2227, C2510], in pharmaceuticals and blood serum by HPLC
- V. F. Samanidou, C. E. Demetriou, I. N. Papadoyannis, Anal. Bioanal. Chem. 2003, 375, 623.
Determination of ofloxacin, norfloxacin [N0817], and ciprofloxacin [C2227, C2510] in sewage by selective solid-phase extraction, liquid chromatography with fluorescence detection, and liquid chromatography-tandem mass spectrometry
- H.-B. Lee, T. E. Peart, M. L. Svoboda, J. Chromatogr. A 2007, 1139, 45.

Application

Studies of the Antimicrobial Activity and the Determination of Ofloxacin

References

Quinolones in 2005: an update
- F. Van Bambeke, J.-M. Michot, J. Van Eldere, P. M. Tulkens, Clin. Microbiol. Infect. 2005, 11, 256.
In vitro and in vivo activity of DL-8280, a new oxazine derivative
- K. Sato, Y. Matsuura, M. Inoue, T. Une, Y. Osada, H. Ogawa, S. Mitsuhashi, Antimicrob. Agents Chemother. 1982, 22, 548.
Fourth generation fluoroquinolones: New weapons in the arsenal of ophthalmic antibiotics
- R. Mather, L. M. Karenchak, E. G. Romanowski, R. P. Kowalski, Am. J. Ophthalmol. 2002, 133, 463.
Direct determination of four fluoroquinolones, enoxacin, norfloxacin, ofloxacin, and ciprofloxacin, in pharmaceuticals and blood serum by HPLC
- V. F. Samanidou, C. E. Demetriou, I. N. Papadoyannis, Anal. Bioanal.Chem. 2003, 375, 623.

PubMed Literature

Documents

Antimicrobials and Antitumors for Research and Experimental Use

Pharmaceutical Ingredients for Research and Experimental Use

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6-Membered Heterocyclic Compounds [Chemical Structural Class]

Oxazines [Chemical Structural Class]

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6-Membered Heterocyclic Compounds [Chemical Structural Class]

Oxazines [Chemical Structural Class]

Product Number	O0403
Purity / Analysis Method	>98.0%(T)(HPLC)
Molecular Formula / Molecular Weight	C__1__8H__2__0FN__3O__4 = 361.37
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
Condition to Avoid	Light Sensitive
CAS RN	82419-36-1
Reaxys Registry Number	3657947
PubChem Substance ID	172089006
Merck Index (14)	6771
MDL Number	MFCD00226105

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CAS RN: 82419-36-1 | Product Number: O0403

Ofloxacin

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CAS RN: 82419-36-1 | Product Number: O0403

Ofloxacin

References

References

Documents

Safety Data Sheet (SDS)

Specifications

C of A & Other Certificates

Sample C of A

Analytical Charts

Other Documents

Product Categories

Chemicals by Class

Life Science

Chemicals by Class

Life Science

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