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CAS RN: 103628-48-4 | Product Number: S0851

Sumatriptan Succinate

Purity: >98.0%(T)(HPLC)
  • 3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl-N-methylmethanesulfonamide Succinate
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1   ≥20 

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Product Number S0851
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__4H__2__1N__3O__2S·C__4H__6O__4 = 413.49  
Physical State (20 deg.C) Solid
CAS RN 103628-48-4
Related CAS RN 103628-46-2
Reaxys Registry Number 5371868
PubChem Substance ID 160871034
Merck Index (14) 8997
MDL Number


Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 165.0 to 169.0 °C
Properties (reference)
Melting Point 167 °C
Solubility in water Soluble
Degree of solubility in water 170 g/l   24 °C
Solubility (very slightly) Methanol
Solubility (insoluble in) Ether,Ethanol
Pictogram Pictogram
Signal Word Danger
Hazard Statements H318 : Causes serious eye damage.
Precautionary Statements P280 : Wear eye protection/ face protection.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
Related Laws:
RTECS# EJ9940000
Transport Information:
Sumatriptan Succinate: A Selective 5-HT1B/1D Receptor Agonist

Sumatriptan succinate is a selective 5-HT1B/1D receptor agonist, belongs to triptans. Sumatriptan binds with high affinity to 5-HT1 receptor subtypes (5-HT1B, 5-HT1D), but has only a week affinity for a serotonergic receptor subtype (5-HT1A) and has no significant affinity for serotonergic receptor subtypes (5-HT1c, 5-HT2, 5-HT3) or for adrenergic (α1, α2, β), dopamine (D1, D2), muscarinic, or benzodiazepine receptors. Animal studies shows that sumatriptan presumably exerts its therapeutic effects in the treatment of migraine headache through agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system. In addition, the transdermal iontophoretic patch of sumatriptan succinate is developed. (The product is for research purpose only.)


PubMed Literature

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