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CAS RN: 64-75-5 | Product Number: T2525

Tetracycline Hydrochloride


Purity: >98.0%(T)
Synonyms:
Documents:
25G
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100G
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Product Number T2525
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__2__2H__2__4N__2O__8·HCl = 480.90 
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Light Sensitive,Heat Sensitive
CAS RN 64-75-5
Related CAS RN 60-54-8
Reaxys Registry Number 3844873
PubChem Substance ID 87560362
Merck Index (14) 9196
MDL Number

MFCD00078142

Specifications
Appearance Light yellow to Amber to Dark green powder to crystal
Purity(HPLC) min. 95.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Specific rotation [a]20/D -240 to -255 deg(C=0.5, 0.1mol/L HCl)
Properties (reference)
Melting Point 214 °C(dec.)
Specific Rotation -253° (C=0.5,0.1mol/L HCl)
Solubility in water Soluble
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# QI9100000
Transport Information:
Application
Tetracycline: a Broad Spectrum Polyketide Antibiotic and a Selective Reagent Genetically Engineered Cells

Tetracycline is a polyketide antibiotic isolated from Streptomyces genus. Tetracycline has broad activity against Gram-negative bacteria and Gram-positive bacteria, with a few exceptions, such as Pseudomonas aeruginosa and Proteus species. Tetracycline inhibits protein synthesis in susceptible organisms by binding to the A-site on the 50S subunit of a bacterial ribosome. However, tetracycline-resistant bacterial strains appeared soon after its introduction. Tetracycline is used in molecular biology as a selective reagent most commonly to isolate bacteria coupled to a gene coding for tetracycline resistance, which is one of the most frequently used selection markers for obtaining transgenic cells. Recently, tetracycline is used for tetracycline-controlled transcriptional activation systems in cells.

References


PubMed Literature


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