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CAS RN: 105826-92-4 | Product Number: T2743
Tropisetron Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-Indole-3-carboxylate Hydrochloride
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
₹5,600.00
|
Contact Us | 1 |
|
| 5G |
₹10,200.00
|
Contact Us | 5 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | T2743 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__0N__2O__2·HCl = 320.82 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 105826-92-4 |
| Related CAS RN
|
89565-68-4 |
| Reaxys Registry Number | 8883131 |
| PubChem Substance ID | 160871173 |
| Merck Index (14) | 9783 |
| MDL Number | MFCD00210221 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 285 °C(dec.) |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | NL6012520 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
Application
Tropisetron hydrochloride: A Selective Competitive 5-HT3 Receptor Antagonist
Tropisetron hydrochloride is a selective competitive antagonist of 5-hydroxytryptamine 3 (5-HT3) receptor which is a subclass of serotonin receptors. 5-HT3 receptors are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, known as the emetic center of the brain. Therefore, tropisetron is used for the prevention of chemotherapy-induced nausea and vomiting.1,2) Tropisetron is mainly metabolized by cytochrome P450 (CYP) 2D6.3) In 2000’s, it has been reported that tropisetron is also a selective partial agonist at α7 nicotinic acetylcholine receptors (α7nAChRs). 4,5) (The product is for research purpose only.)
References
- 1)Effects of conditioned fear stress on 5-HT release in the rat prefrontal cortex
- 2)Tropisetron: An update of its use in the prevention of chemotherapy-induced nausea and vomiting (a review)
- 3)Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting (a review)
- 4)The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective α7 nicotinic receptor partial agonist
- 5)Molecular dissection of tropisetron, an α7 nicotinic acetylcholine receptor-selective partial agonist
- 6)Simultaneous determination of ondansetron and tropisetron in human plasma using HPLC with UV detection
- 7)HPLC, TLC, and first-derivative spectrophotometry stability-indicating methods for the determination of tropisetron in the presence of its acid degradates
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Specifications
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