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CAS RN: 220620-09-7 | Product Number: T3589
Tigecycline
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Purity: >98.0%(HPLC)
Synonyms:
- 9-tert-Butylglycylamidominocycline
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
₹9,700.00
|
4 | ≥40 |
|
| 500MG |
₹14,600.00
|
3 | 26 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | T3589 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__9H__3__9N__5O__8 = 585.66 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 220620-09-7 |
| Reaxys Registry Number | 8379453 |
| PubChem Substance ID | 354335260 |
| Merck Index (14) | 9432 |
| MDL Number | MFCD00935753 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Specific rotation [a]20/D | -189 to -208 deg(C=0.15, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 185 °C(dec.) |
| Specific Rotation | -199° (C=0.15,CH3OH) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H318 : Causes serious eye damage. H360 : May damage fertility or the unborn child. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P405 : Store locked up. |
Related Laws:
| RTECS# | QI7619500 |
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
Application
Tigecycline: The First Glycylcycline Antimicrobial Agent with Activity against Multidrug-Resistant Strains
Tigecycline (GAR-936) is the first glycylcycline antimicrobial agent with expanded broad-spectrum activity against both Gram-negative (except for Pseudomonas aeruginosa) and Gram-positive aerobes and anaerobes. Furthermore, the spectrum of activity extends to multidrug-resistant strains of Staphylococcus aureus (MRSA), Streptococcus pneumoniae, vancomycin-resistant enterococci (VRE), and Enterobacteriaceae, including extended-spectrum β-lactamase (ESBL) producing strains. In addition, tigecycline is able to overcome the major resistance mechanisms, ribosomal protection and efflux. Tigecycline inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of aminoacyl-tRNA molecules into the A site of the ribosome. Tigecycline binds to bacterial ribosomes in a novel way that allows it to overcome tetracycline resistance due to ribosomal protection. (The product is for research purpose only.)
References
- In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936)
- Functional, biophysical, and structural bases for antibacterial activity of tigecycline
- Tigecycline for the treatment of multidrug-resistant (including carbapenem-resistant) Acinetobacter infections: a review of the scientific evidence (a review)
- Tigecycline: an update (a review)
- Quantitation of tigecycline, a novel glycyclcycline, by liquid chromatography
- Simultaneous analysis of antibiotics in biological samples by ultra high performance liquid chromatography-tandem mass spectrometry
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Specifications
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