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CAS RN: 6846-35-1 | Product Number: X0001
Xanthane Hydride
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Purity: >96.0%(HPLC)
Synonyms:
- ADTT
- 5-Amino-3H-1,2,4-dithiazole-3-thione
- 3-Amino-1,2,4-dithiazole-5-thione
- 5-Imino-5H-[1,2,4]dithiazole-3-thiol
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
₹10,400.00
|
3 | ≥100 |
|
| 100G |
₹21,200.00
|
2 | 17 |
|
| 500G |
₹25,900.00
|
5 | ≥80 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | X0001 |
Purity / Analysis Method 
|
>96.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2H__2N__2S__3 = 150.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 6846-35-1 |
| Reaxys Registry Number | 112403 |
| PubChem Substance ID | 87577871 |
| SDBS (AIST Spectral DB) | 3701 |
| MDL Number | MFCD00051660 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(with Total Nitrogen) | min. 96.0 % |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | JO6500000 |
Transport Information:
Application
Sulfur-Transfer Reagents for Synthesis of Oligonucleotide Phosphorothioates
References
- Nucleic acid therapeutics: basic concepts and recent developments
- 3H-1,2-Benzodithiol-3-one 1,1-dioxide
- Phosphorothioate Oligonucleotides with Low Phosphate Diester Content: Greater than 99.9% Sulfurization Efficiency with “Aged” Solutions of Phenylacetyl Disulfide (PADS)
- Large-Scale Synthesis of Oligonucleotide Phosphorothioates Using 3-Amino-1,2,4-dithiazole-5-thione as an Efficient Sulfur-Transfer Reagent
- Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride)
Application
Xanthane Hydride: A Sulfur-Transfer Reagent for Synthesis of Oligonucleotide Phosphorothioates
Xanthane hydride (3-amino-1,2,4-dithiazole-5-thione), Beaucage Reagent [B3125] and Bis(phenylacetyl) disulfide [B3623] are used as a sulfur-transfer reagent for synthesis of oligonucleotide phosphorothioates via the phosphoramidite method.1-4) In particular, xanthane hydride has advantages because it does not yield oxidizing substances, carbon disulfide and cyanamide as the additional reaction products.2,3) For DNA/RNA synthesizer, xanthane hydride solution is used, such as 0.02 M solution in acetonitrile/pyridine (9:1),1) or 0.20 M solution in pyridine.4)
References
- 1)Large-Scale Synthesis of Oligonucleotide Phosphorothioates Using 3-Amino-1,2,4-dithiazole-5-thione as an Efficient Sulfur-Transfer Reagent
- 2)Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride)
- 3)Evidence for the formation of isothiocyanate during sulfurisation of phosphines and phosphites using xanthane hydride
- 4)Synthesis of 5’-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies
PubMed Literature
Documents
Product Articles
[Product Highlights] Sulfur-Transfer Reagents for Synthesis of Oligonucleotide PhosphorothioatesProduct Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Other Documents
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