It has come to our notice that certain fraudulent individuals or entities are misusing our Company’s name and TCI’s registered trademarks by promoting and offering regulated and hazardous chemical substances through online platforms like YouTube. We hereby categorically clarify that TCI has no association or connection whatsoever with the products being displayed or sold in the videos. These products have been falsely represented as being associated with TCI, and the unauthorized use of our trademark and brand name is both illegal and misleading. TCI Chemicals markets and sells its products exclusively through its official website and authorized distributors. If you become aware of any such fraudulent activity or require clarification, you may reach out to us at: Sales-IN@TCIchemicals.com. Click Here to View the Caution Notice.
Product Document Searching Made Easy by 2D Code! | [Product Highlights] Endogenous Biotin-Blocking Reagent...Maximum quantity allowed is 999
TCI Practical Example: Synthesis of Primary Sulfonamides Using tBuONSO
We are proud to present the synthesis of the primary sulfonamide using tBuONSO and p-tolylmagnesium bromide. tBuONSO is a reagent for the synthesis of primary sulfonamides with organometallic reagents such as Grignard reagents and organolithium reagents.
-
Used Chemicals
-
Procedure
-
p-Tolylmagnesium bromide (ca. 1 mol/L, 4.4 mL, 4.4 mmol) was added to a solution of tBuONSO (400 mg, 2.96 mmol) in anhydrous THF (12 mL) at -78 °C and the mixture was stirred at the same temperature for 1 hour. The suspension was warmed to room temperature and stirred for overnight. After that, methanol (1 mL) was add to the reaction mixture and the solvent was removed under reduced pressure. The residue was purified by column chromatography (ethyl acetate:hexane = 0:1 - 1:4 on silica gel) to give 4-methylbenzenesulfonamide as a white solid (407 mg, 80%).
-
Experimenter’s Comments
-
The reaction mixture was monitored by UPLC.
-
Analytical Data
-
4-Methylbenzenesulfonamide
1H NMR (400 MHz, CDCl3); δ 7.70 (d, J = 8.4 Hz, 2H), 7.36 (d, J = 8.1 Hz, 2H), 7.27 (brs, 2H), 2.33 (s, 3H).
-
Lead Reference
-
- Primary Sulfonamide Synthesis Using the Sulfinylamine Reagent N‑Sulfinyl‑O‑(tert-butyl)hydroxylamine, t‑BuONSO
