It has come to our notice that certain fraudulent individuals or entities are misusing our Company’s name and TCI’s registered trademarks by promoting and offering regulated and hazardous chemical substances through online platforms like YouTube. We hereby categorically clarify that TCI has no association or connection whatsoever with the products being displayed or sold in the videos. These products have been falsely represented as being associated with TCI, and the unauthorized use of our trademark and brand name is both illegal and misleading. TCI Chemicals markets and sells its products exclusively through its official website and authorized distributors. If you become aware of any such fraudulent activity or require clarification, you may reach out to us at: Sales-IN@TCIchemicals.com. Click Here to View the Caution Notice.
Product Document Searching Made Easy by 2D Code! | [Product Highlights] Endogenous Biotin-Blocking Reagent...Maximum quantity allowed is 999
TCI Practical Example: Dehydration Reaction of an Amide by Using Cyanuric Chloride
We are proud to present the synthesis of 4-bromobenzonitrile by the dehydration of 4-bromobenzamide by using cyanuric chloride.
-
Used Chemicals
-
Procedure
-
Cyanuric chloride (183 mg, 1.0 mmol, 0.67 eq.) was added to a solution of 4-bromobenzamide (300 mg, 1.5 mmol) in DMF (3 mL) at 0 °C. The mixture was stirred at room temperature for 3.5 hours and quenched with water (15 mL). The solution was extracted with ethyl acetate (15 mL x 3) and the organic layer was washed with 2 mol/L HCl (15 mL), sat. NaHCO3 aq. (15 mL), and brine (15 mL), dried over sodium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by column chromatography (on silica gel, ethyl acetate:hexane = 1:4) to give 4-bromobenzonitrile as a pale white solid (260 mg, 95% yield).
-
Experimenter's Comments
-
The reaction mixture was monitored by UPLC.
-
Analytical Data
-
4-bromobenzonitrile
1H NMR (400 MHz, CDCl3); δ 7.64 (d, 2H, J = 8.4 Hz), 7.53 (d, 2H, J = 8.4 Hz).
-
Lead Reference
-
- (S)-5-Pyrrolidin-2-yl-1H-Tetrazole
