It has come to our notice that certain fraudulent individuals or entities are misusing our Company’s name and TCI’s registered trademarks by promoting and offering regulated and hazardous chemical substances through online platforms like YouTube. We hereby categorically clarify that TCI has no association or connection whatsoever with the products being displayed or sold in the videos. These products have been falsely represented as being associated with TCI, and the unauthorized use of our trademark and brand name is both illegal and misleading. TCI Chemicals markets and sells its products exclusively through its official website and authorized distributors. If you become aware of any such fraudulent activity or require clarification, you may reach out to us at: Sales-IN@TCIchemicals.com. Click Here to View the Caution Notice.
Product Document Searching Made Easy by 2D Code! | [Product Highlights] Endogenous Biotin-Blocking Reagent...Maximum quantity allowed is 999
Please select the quantity
Intramolecular Cyclization
No.138(August 2009)
6-Heptynenitrile (1) was treated with n-BuLi，chlorodiethylaminodimethylsilane, followed by reaction with propargyl alcohol to afford diynenitrile 2. Treatment of 2 with diethylcyclopentadienylcobalt catalyst afforded tetrahydroquinoline derivative 3 by intramolecular cyclisation. Subsequent treatment of this with KHCO3 and TBAF gave the desilylated tetrahydroquinoline 4. Alternatively, Tamao-Fleming oxidation of 3 with H2O2, KHCO3 and TBAF, gave diol 5 in high yield.
References
- 1)Cobalt-mediated regioselective synthesis of substituted tetrahydroquinolines
- 2)Cobalt(I)-catalyzed cycloaddition
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.