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Human Serum Albumin (Drug Site 2) Binding Fluorescent Probe: BD140
No.174(July 2017)
Human Serum Albumin (HSA）is known to interact with various compounds like fatty acids, proteins, and low molecular weight drugs. HSA has mainly two drug binding sites in its molecule, drug site 1 (site 1) and drug site 2 (site 2). It has been reported that Warfarin and other low molecular weight drugs bind to site 1, whereas Ibuprofen and other low molecular weight drugs bind to site 2. Therefore, investigating whether drugs bind to HSA and identifying the drug binding site on HSA are important for pharmacokinetics. Dansylamide and other probes for site 1 and dansylglycine and other probes for site 2 have been applied to investigate the binding site of low molecular weight drugs so far. On the other hand, BD140 (1), developed by Chang et al., is a novel fluorescent probe specifically binding to HSA drug binding site 2.1) Thus, BD140 is a useful tool to check whether drugs bind to HSA drug binding site 2.
The product is for research purpose only.
References
- Fluorescent Dye Cocktail for Multiplex DrugSite Mapping on Human Serum Albumin
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