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Product Document Searching Made Easy by 2D Code! | [Product Highlights] Endogenous Biotin-Blocking Reagent...Maximum quantity allowed is 999
Spiroheptadiene Reagents to React with Maleimide to Modify Antibodies
N6-[(Spiro[2.4]hept-4,6-dien-1-ylmethoxy)carbonyl]-L-lysine (1) enables the site-specific modification of proteins, making it useful for the preparation of homogeneous antibody-drug conjugates (ADCs).1) The spiroheptadiene (SCp) moiety of 1, introduced into a specific site of the protein by genetic code expansion, reacts with the maleimide moiety at a rate of 1.8-5.4 M-1 s-1 with the Diels-Alder reaction to form a 6-membered ring.2) ADCs obtained by reacting 1-incorporated antibodies with drug-conjugated maleimides exhibit better stability and efficacy than cysteine-maleimide conjugates both in mouse serum and in vivo.
We also offer 4-nitrophenyl spiro[2.4]hepta-4,6-dien-1-ylmethyl carbonate (2) as a reagent to introduce SCp moiety.
References
- 1) Click chemistry in the synthesis of antibody-drug conjugate
- 2) A Reactive Antibody Platform for One-Step Production of Antibody-Drug Conjugates through a Diels-Alder Reaction with Maleimide
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