Retinoic Acid Receptors Agonist

TTNPB (1) is a synthetic stilbene retinoid analog of retinoic acid and acts as a retinoic acid receptor (RAR) agonist (Table 1).¹⁾ 1 also enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).²⁾

References

• 1) Synthesis and Structure-Activity Relationships of Stilbene Retinoid Analogs Substituted with Heteroaromatic Carboxylic Acids
  • R. L. Beard, R. A. S. Chandraratna, D. F. Colon, S. J. Gillett, E. Henry, D. K. Marler, T. Song, L. Denys, M. E. Garst, T. Arefieg, E. Klein, D. W. Gil, L. Wheeler, D. M. Kochhar, P. J. A. Davies, J. Med. Chem. 1995, 38, 2820.
• 2) Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
  • P. Hou, Y. Li, X. Zhang, C. Liu, J. Guan, H. Li, T. Zhao, J. Ye, W. Yang, K. Liu, J. Ge, J. Xu, Q. Zhang, Y. Zhao, H. Deng, Science 2013, 341, 651.

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