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CAS RN: 69123-98-4 | Product Number: D4200
Fialuridine
×
Purity: >98.0%(HPLC)
Synonyms:
- 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil
- FIAU
- 2'-Fluoro-5-iodoarauracil
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
¥21,200
|
1 | 1 | It can be shipped in about 2 weeks after ordering |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | D4200 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__0FIN__2O__5 = 372.09 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 69123-98-4 |
| Reaxys Registry Number | 892318 |
| PubChem Substance ID | 160871154 |
| Merck Index (14) | 4069 |
| MDL Number | MFCD00866922 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 226 °C |
GHS
Related Laws:
| RTECS# | YQ9512500 |
Transport Information:
Application
Fialuridine (FIAU): A Thymidine Nucleoside Analog with Activity against Herpes Viruses and Hepatitis B Virus (HBV)
Fialuridine (FIAU) is a thymidine nucleoside analog with activity against various herpes viruses and hepatitis B virus (HBV). FIAU blocks the action of DNA polymerases, thus inhibiting viral replication. FIAU owes its effect to preferential phosphorylation by virus-encoded thymidine kinase to its 5'-diphosphate form. After further conversion to triphosphate form, it acts as an inhibitor or alternate substrate for the viral DNA polymerase. On the other hand, it appear that FIAU causes mitochondrial toxicity leading to fatal liver failure alongside lactic acidosis. (The product is for research purpose only.)
References
- Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analog for chronic hepatitis B
- Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase
- Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection
- Review article: Mechanisms for the anti-hepatitis B virus activity and mitochondrial toxicity of fialuridine (FIAU)
PubMed Literature
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