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CAS RN: 10347-81-6 | Product Number: M2527
Maprotiline Hydrochloride

Purity: >98.0%(T)(HPLC)
Synonyms:
- 9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene Hydrochloride
Product Documents:
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* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Product Number | M2527 |
Purity / Analysis Method ![]() |
>98.0%(T)(HPLC) |
Molecular Formula / Molecular Weight | C__2__0H__2__3N·HCl = 313.87 |
Physical State (20 deg.C) | Solid |
Storage Temperature ![]() |
Room Temperature (Recommended in a cool and dark place, <15°C) |
Packaging and Container ![]() |
1G-Glass Bottle with Plastic Insert (View image) |
CAS RN | 10347-81-6 |
Related CAS RN ![]() |
10262-69-8 |
Reaxys Registry Number | 5463242 |
PubChem Substance ID | 253661753 |
Merck Index (14) | 5748 |
MDL Number | MFCD00079464 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
Melting point | 240.0 to 244.0 °C |
Properties (reference)
Melting Point | 242 °C |
Solubility (soluble in) | Methanol |
Solubility (slightly sol. in) | Ethanol |
GHS
Pictogram |
![]() |
Signal Word | Warning |
Hazard Statements | H302 : Harmful if swallowed. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
RTECS# | KJ4555000 |
Transport Information:
Application
Maprotiline: An Inhibitor of Norepinephrine Uptake
Maprotiline, a tetracyclic second-generation antidepressant, exhibits strong inhibitory effects on norepinephrine uptake but interferes relatively little on serotonin and dopamine reuptake. Maprotiline is metabolized by polymorphic CYP2D6 and CYP2Cl9 isoforms in the liver. (The product is for research purpose only.)
References
- Maprotiline: a review of its pharmacological properties and therapeutic efficacy in mental depressive states
- Chemistry, Pharmacology, Pharmacokinetics, Adverse Effects, and Efficacy of the Antidepressant Maprotiline Hydrochloride (a review)
- Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine
- Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine
- Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats
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