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Published TCIMAIL newest issue No.185.
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CAS RN: 63208-82-2 | Product Number: P2751
Pifithrin-α
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide
Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
|---|---|---|---|---|
| 10MG |
¥15,800
|
3 | Contact Us | ≥20 |
| 50MG |
¥56,500
|
10 | 1 | ≥20 |
Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock in other WH: 2-3 Business Days
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* Please contact us if you need further information.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | P2751 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__8N__2OS·HBr = 367.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | -20°C |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 63208-82-2 |
| Reaxys Registry Number | 4943838 |
| Merck Index (14) | 7421 |
| MDL Number | MFCD00417851 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentmetric Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 192 °C |
GHS
Related Laws:
| RTECS# | KM5784250 |
Transport Information:
Application
Pifithrin-α (PFT-α): A p53 Inhibitor
p53 (Also known as Trp53 in mice, TP53 in humans) is a tumor suppressor protein that is frequently inactivated in tumors.1) Pifithrin-α (PFT-α) is a p53 inhibitor that blocks p53-dependent transcriptional activation and apoptosis.2-4) Other p53 Inhibitors: Cyclic Pifithrin-α Hydrobromide [C2826] and Pifithrin-μ [P2048].
References
- 1) Assessing TP53 status in human tumours to evaluate clinical outcome
- 2) A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
- 3) Suppression of p53: a new approach to overcome side effects of antitumor therapy (a review)
- 4) Prospective therapeutic applications of p53 inhibitors (a review)
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