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CAS RN: 213416-70-7 | Product Number: P3154
PIPER
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Purity: >95.0%(HPLC)
Synonyms:
- 2,9-Bis[2-(piperidin-1-yl)ethyl]anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetraone
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
¥10,000
|
10 | ≥40 | 1 | |
| 25MG |
¥35,000
|
10 | ≥40 | It can be shipped in about 3-4 weeks after ordering |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | P3154 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__8H__3__6N__4O__4 = 612.73 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 213416-70-7 |
| Reaxys Registry Number | 9109510 |
| MDL Number | MFCD02179210 |
Specifications
| Appearance | Red to Dark red to Dark purple powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
Application
PIPER: A Potent Telomerase Inhibitor
PIPER is a potent telomerase inhibitor used in cancer research. It inhibits human telomerase by binding to G-quadruplex DNA. Cancer cells evade replicative senescence by re-expressing telomerase, which maintains telomere length and thus chromosomal integrity. Therefore, inhibiting telomerase would cause cancer cells to senesce and thus prevent cancer cells from growing indefinitely. (The product is for research use only.)
References
- NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA
- Accelerated Assembly of G-Quadruplex Structures by a Small Molecule
- Inhibition of Unwinding of G-Quadruplex Structures by Sgs1 Helicase in the Presence of N,N‘-Bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, a G-Quadruplex-Interactive Ligand
- Perylene diimides with different side chains are selective in inducing different G-quadruplex DNA structures and in inhibiting telomerase
- G-quadruplex DNA: a potential target for anti-cancer drug design (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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