DNAメチルトランスフェラーゼ阻害剤

　RG 108 (1)はDNAメチルトランスフェラーゼ阻害剤で，IC₅₀ = 115 nMで酵素を阻害します^1,2)。1は酵素の活性部位に直接結合することが分子モデリングによって示されています¹⁾。また，1はヒト³⁾及びマウス^4,5)の体細胞のiPS細胞への再プログラミングを促進します。

文献

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