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CAS RN: 320-67-2 | Product Number: A2033
5-Azacytidine
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Purity: >98.0%(T)
Synonyms:
- 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
- Ladakamycin
Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 100MG |
₩ 65,600
|
≥20 | ≥20 |
| 1G |
₩ 334,400
|
10 | ≥20 |
* Please contact our distributor of SEJIN CI
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination.
* SEJIN CI (Phone: 02-2655-2480 / email: sales@sejinci.co.kr)
* SEJIN CI (Phone: 02-2655-2480 / email: sales@sejinci.co.kr)
| Product Number | A2033 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__8H__1__2N__4O__5 = 244.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | <0°C |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 320-67-2 |
| Reaxys Registry Number | 620461 |
| PubChem Substance ID | 87559665 |
| Merck Index (14) | 887 |
| MDL Number | MFCD00006539 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 216 °C(dec.) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H340 : May cause genetic defects. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | XZ3017500 |
Transport Information:
| H.S.code* | 2940.00-000 |
Application
An Inhibitor of DNA Methylation
The cytidine analogs 5-azacytidine and 5-aza-2'-deoxycytidine [A2232] are inhibitors of DNA methyltransferases (DNMTs) which catalyze the transfer of a methyl group to DNA. DNA methylation is an epigenetic factor and plays an important role in regulating gene expression. 5-Azacytidine and 5-aza-2'-deoxycytidine are the currently most advanced agents for epigenetic cancer therapies. (The product is for research purpose only.)
References
- Cellular differentiation, cytidine analogs and DNA methylation
- 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy (a review)
- The Role of Methylation in Gene Expression (a review)
- Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
- Quantification of 5-azacytidine in plasma by electrospray tandem mass spectrometry coupled with high-performance liquid chromatography
Application
Aminophylline: A Water Soluble Theophylline
References
- Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
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