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CAS RN: 863329-66-2 | Product Number: D4823
PSI-6206
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
- RO 2433
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
₩37,100
|
14 | 14 | Contact Us | |
| 1G |
₩119,000
|
14 | 11 | Contact Us |
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* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | D4823 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__3FN__2O__5 = 260.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 863329-66-2 |
| Reaxys Registry Number | 10267735 |
| PubChem Substance ID | 253661201 |
| MDL Number | MFCD27918669 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +87.0 to +92.0 deg(C=1,MeOH) |
Properties (reference)
| Melting Point | 234 °C(dec.) |
| Specific Rotation | 89° (C=1,MeOH) |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
A Selective Nucleoside Polymerase Inhibitor of Hepatitis C Virus (HCV)
(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine (other name: PSI-6206 or β-D-2'-deoxy-2'-fluoro-2'-C-methyluridine) is a selective nucleoside polymerase inhibitor of hepatitis C virus (HCV) replication that targets the NS5B polymerase. Recently, to improve pharmacokinetic properties for clinical use, some prodrugs of the 5'-phosphate derivative of PSI-6206 have been developed. In addition, PSI-6206 is an active metabolite of PSI-6130 (β-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine).
References
- Pharmacokinetics of the antiviral agent β-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine in rhesus monkeys
- The mechanism of action of β-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to β-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
- Discovery of a β-D-2'-Deoxy-2'-α-fluoro-2'-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
- Synthesis of Diastereomerically Pure Nucleotide Phosphoramidates
- Synthesis of 5'-Methylene-Phosphonate Furano-nucleoside Prodrugs: Application to D-2'-Deoxy-2'-α-fluoro-2'-β-C-methyl Nucleosides
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