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CAS RN: 273404-37-8 | Product Number: V0176
VX-765
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Purity: >95.0%(HPLC)
Synonyms:
- Belnacasan
- N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxy-5-oxotetrahydro-3-furanyl]-L-prolinamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
₩247,700
|
12 | 0 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | V0176 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__3__3ClN__4O__6 = 509.00 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 273404-37-8 |
| Reaxys Registry Number | 11023248 |
| PubChem Substance ID | 468593118 |
| MDL Number | MFCD11100350 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 99 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
VX-765: A Potent and Selective Inhibitor of the Enzyme Caspase 1
VX-765 is an orally absorbed prodrug of VRT-043198 which is a potent and selective inhibitor of the enzyme Caspase 1 which is involved in inflammation and cell death.1,2) It has recently been reported that NLR family pyrin domain-containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called NLRP3 inflammasome in response to irritating metabolites and pathogens, and induces the production of pro-inflammatory cytokines, Interleukin (IL)-1β and IL-18. VX765 has also attracted attention as a NLRP3 inflammasome inhibitor which shows anti-inflammatory activity.3,4) (The product is for research purpose only.)
References
- 1) (S)-1-((S)-2-{[1-(4-Amino-3-chlorophenyl)methanoyl]amino}-3,3-dimethylbutanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1β and IL-18
- 2) IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients
- 3) NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice
- 4) Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis
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