HPMC Capsule Reagents for Accelerating Synthetic Chemistry

TCI sells capsule reagents, which are synthetic reagents encapsulated in hydroxypropyl methylcellulose (HPMC) capsules. By using capsule reagents, weighing of reagents can be omitted, and reactions can be initiated simply by adding them to the reaction solution, thereby enabling rapid investigational experiments and library construction.^1-3) The lineup includes condensing reagents, reagents for photoredox reactions, and reagents for Suzuki-Miyaura cross-coupling reactions, which are frequently used in drug discovery research and synthetic organic chemistry, and the lineup is currently being expanded.

References

• 1) Reagent and Catalyst Capsules: A Chemical Delivery System for Reaction Screening and Parallel Synthesis
  • N. Borlinghaus, J. Kaschel, J. Klee, V. Haller, J. Schetterl, S. Heitz, T. Lindner, J. D. Dietrich, W. M. Braje, A. Jolit, J. Org. Chem. 2021, 86, 1357.
• 2) HPMC: A Biomass-Based Semisynthetic Sustainable Additive Enabling Clean and Fast Chemistry in Water
  • S. Sharma, T. N. Ansari, S. Handa, ACS Sustainable Chem. Eng. 2021, 9, 12719.
• 3) Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water
  • D. Petkova, N. Borlinghaus, S. Sharma, J. Kaschel, T. Lindner, J. Klee, A. Jolit, V. Haller, S. Heitz, K. Britze, J. Dietrich, W. M. Braje, S. Handa, ACS Sustainable Chem. Eng. 2020, 8, 12612.

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