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CAS RN: 25389-94-0 | Product Number: K0047

Kanamycin Monosulfate


Purity: >94.0%(N)
Synonyms:
  • O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine Monosulfate
Documents:
5G
€26.00
4   ≥20 
25G
€78.00
4   ≥20 

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Product Number K0047
Purity / Analysis Method >94.0%(N)
Molecular Formula / Molecular Weight C__1__8H__3__6N__4O__1__1·H__2SO__4 = 582.58  
Physical State (20 deg.C) Solid
CAS RN 25389-94-0
Related CAS RN 59-01-8&8063-07-8
Reaxys Registry Number 3874279
PubChem Substance ID 87560322
Merck Index (14) 5281
MDL Number

MFCD00070253

Specifications
Appearance White to Almost white powder to crystal
Purity(with Total Nitrogen) min. 94.0 %
Specific rotation [a]20/D +112 to +123 deg(C=1, H2O)(calcd.on dried substance)
Drying loss max. 4.0 %
Properties (reference)
Melting Point 250 °C(dec.)
Specific Rotation 117.5° (C=1,H2O)
Solubility in water Soluble
GHS
Related Laws:
EC Number 246-933-9
RTECS# NZ3225030
Transport Information:
HS Number 2941900000
Application
Kanamycin: A Broad Spectrum Aminoglycoside Antibiotic and a Selective Reagent Genetically Engineered Cells

Kanamycin, an aminoglycoside antibiotic, was first isolated in 1957 from the bacterium Streptomyces kanamyceticus by Umezawa. Kanamycin has broad activity against Gram-negative bacteria and Gram-positive bacteria, including Mycobacterium tuberculosis. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Kanamycin is used in molecular biology as a selective reagent most commonly to isolate bacteria (e.g., Escherichia coli.) coupled to a gene coding for kanamycin resistance, which is one of the most frequently used selection markers for obtaining transgenic cells.

References


PubMed Literature


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