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Published TCIMAIL newest issue No.198
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CAS RN: 137281-23-3 | Product Number: P2288
Pemetrexed
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Purity: >98.0%(T)(HPLC)
Synonyms:
- N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
€54.00
|
1 | ≥40 |
|
| 1G |
€165.00
|
1 | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2288 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__1N__5O__6 = 427.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 137281-23-3 |
| Related CAS RN | 1916503-69-9 |
| Reaxys Registry Number | 9097855 |
| PubChem Substance ID | 253661102 |
| Merck Index (14) | 7077 |
| MDL Number | MFCD19105065 |
Specifications
| Appearance | White to Blue powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 %(calcd.on anh.substance) |
| Water | 2.0 to 11.0 % |
Properties (reference)
| Solubility (slightly sol. in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| RTECS# | LZ9950100 |
Transport Information:
| HS Number | 2933998090 |
Application
Pemetrexed: A Multitargeted Antifolate
Pemetrexed is an antimetabolite that inhibits at least three enzymes involved in the folate pathway. These enzymes are thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT) which are used in purine and pyrimidine synthesis. Therefore, pemetrexed prevents the formation of DNA and RNA which are required for the growth of both normal cells and tumor cells. Pemetrexed has demonstrated clinical activity in non-small cell lung cancer and mesothelioma as well as in a broad array of other solid tumors. For your reference, [A2618] and [M2426] are key synthetic intermediates of pemetrexed. (The product is for research purpose only.)
References
- A dideazatetrahydrofolate analog lacking a chiral center at C-6: N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5yl)ethyl[benzoyl]-L-glutamic acid is an inhibitor of thymidylate synthase
- Pemetrexed: A multitargeted antifolate (a review)
- Pemetrexed: Biochemical and cellular pharmacology, mechanisms, and clinical applications (a review)
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