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Published TCIMAIL newest issue No.199
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CAS RN: 255906-59-3 | Product Number: V0173
VK3-OCH3
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Purity: >98.0%(HPLC)
Synonyms:
- 2-[(2-Methoxyethyl)thio]-3-methylnaphthalene-1,4-dione
- 2-[(2-Methoxyethyl)thio]-3-methyl-1,4-naphthoquinone
- 2-(2-Methoxyethylsulfanyl)-3-methylnaphthalene-1,4-dione
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€400.00
|
Contact Us | 17 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | V0173 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__4O__3S = 262.32 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 255906-59-3 |
| Reaxys Registry Number | 35070670 |
| PubChem Substance ID | 468593116 |
| MDL Number | MFCD22575003 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 66.0 to 70.0 °C |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2930909599 |
Application
VK3-OCH3: A Thioether Analog of Vitamin K with a Selective Anti-Tumor Activity
VK3-OCH3 is a thioether analog of vitamin K with a selective anti-tumor activity.1-3) It has been reported that VK3-OCH3 inhibits the activity of protein-tyrosine phosphatases (PTPases), and induces protein-tyrosine phosphorylation in a human hepatoma cell line (Hep3 B).1) In another report, VK3-OCH3 induces G2/M arrest and apoptosis through heme oxygenase-1 (HO-1) related signal transduction in neuroblastoma cells and exhibit less cytotoxicitiy in normal cell lines.2) (The product is for research purpose only.)
References
- 1) Inhibition of hepatoma cell growth in vitro by arylating and non-arylating K vitamin analogs. Significance of protein tyrosine phosphatase inhibition
- 2) Vitamin K3 Analogs Induce Selective Tumor Cytotoxicity in Neuroblastoma
- 3) Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25
Product Documents (Note: Some products will not have analytical charts available.)
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