Sign up for free shipping on all website orders, no minimum required, and get exclusive coupons!
Users can now ask questions to the AI chatbot by clicking the chatbot icon in the bottom-right corner of the website.
Maximum quantity allowed is 999
Please select the quantity
AMP-Activated Protein Kinase (AMPK) Activator
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR, 1) selectively activates AMP-activated protein kinase (AMPK).1) Adamo et al. reported that 1 induces the expression of Klf2 and Klf4 and activates the pluripotency transcriptional network in mouse embryonic stem cells (mESCs).2) In mouse embryonic fibroblasts (MEFs), 1 induces Klf4, Klf2, and Myc upregulation. As shown in Table, 1 antagonizes retinoic acid induced differentiation in mESCs.
Table. Effects of AICAR on the pluripotency transcriptional network in the presence of high doses of retinoic acid.2)
References
- 1) 5-Aminoimidazole-4-Carboxamide Ribonucleoside
A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells? - 2) AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.