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CAS RN: 50-91-9 | Product Number: D2235

2'-Deoxy-5-fluorouridine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 1-(2-Deoxy-β-D-ribofuranosyl)-5-fluorouracil
  • 5-Fluoro-2'-deoxy-β-uridine
  • Floxuridine
  • FUDR
Documents:
100MG
€31.00
2   6  
500MG
€106.00
4   Contact Us
1G
€187.00
7   15  

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number D2235
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__9H__1__1FN__2O__5 = 246.19  
Physical State (20 deg.C) Solid
CAS RN 50-91-9
Reaxys Registry Number 90221
PubChem Substance ID 87568673
SDBS (AIST Spectral DB) 19323
Merck Index (14) 4112
MDL Number

MFCD00006530

Specifications
Appearance White to Yellow to Orange powder to crystal
Purity(GC) min. 99.0 %
Melting point 171.0 to 175.0 °C
Solubility in Acetonitrile very faint turbidity
Properties (reference)
Melting Point 150 °C
Specific Rotation 38° (C=1,H2O)
Solubility in water Soluble
Solubility (soluble in) Acetone,Alcohol
Solubility (insoluble in) Ether,Benzene,Chloroform
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
EC Number 200-072-5
RTECS# YU7525000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
HS Number 2934999090
Application
Floxuridine: An Antitumor Antimetabolite with Inhibition of Thymidylate Synthase

Floxuridine (FUDR), an antitumor antimetabolite, is a prodrug of 5-fluorouracil (5-FU) [F0151]. Floxuridine is rapidly catabolized to 5-FU in vivo. Similarly to 5-FU, floxuridine inhibits thymidilate synthetase (TS) which is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). dTMP forms thymidine, a nucleic acid in deoxyribonucleic acid (DNA). Therefore, the primary effect of floxuridine is to interfere with the synthesis of DNA. (The product is for research purpose only.)

References


PubMed Literature


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