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Published TCIMAIL newest issue No.199
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CAS RN: 147-94-4 | Product Number: C2035
Cytarabine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
- Arabinocytidine
- Cytosine β-D-Arabinofuranoside
- Ara-C
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€32.00
|
Contact Us | ≥60 |
|
| 5G |
€102.00
|
6 | 24 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | C2035 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__3N__3O__5 = 243.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 147-94-4 |
| Related CAS RN
|
69-74-9 |
| Reaxys Registry Number | 89175 |
| PubChem Substance ID | 87558791 |
| Merck Index (14) | 2784 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +155.0 to +162.0 deg(C=1, H2O) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 214 °C |
| Specific Rotation | 158° (C=1,H2O) |
| Maximum Absorption Wavelength | 272 nm (H__2O) |
| Solubility in water | Soluble |
GHS
Related Laws:
| EC Number | 205-705-9 |
| RTECS# | HA5425000 |
Transport Information:
| HS Number | 2934999090 |
Application
Cytarabine (ara-C): D-Arabinosyl Nucleoside exhibiting Anti-Leukemia and Anti-DNA Virus Activities
Certain D-arabinosyl nucleosides, notably cytarabine (ara-C) and vidarabine (ara-A) [V0098] are used as an anti-leukemia agent and an anti-DNA virus agent. Ara-C and ara-A are cell cycle phase-specific antineoplastic agents, affecting cells only during the S-phase of cell division. Intracellularly, ara-C and ara-A are converted into the 5-triphosphates (ara-CTP and ara-ATP), which are the active metabolites. The mechanism of actions are not completely understood, but it appear that ara-CTP and ara-ATP act through the inhibition of tumor cell or virus-induced DNA polymerases, competing with dCTP and dATP, respectively. Incorporation of them into DNA and RNA also contribute to their cytotoxicity. (The product is for research purpose only.)
References
- The mechanisms of lethal action of arabinosyl cytosine (araC) and arabinosyl adenine (araA) (a review)
- Ara-C: cellular and molecular pharmacology (a review)
- Acute Myeloid Leukemia (a review)
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