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CAS RN: 188062-50-2 | 产品编码: A3532
Abacavir Sulfate
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| 产品编码 | A3532 |
| 纯度/分析方法 | >95.0%(T)(HPLC) |
| 分子式/分子量 | C__2__8H__3__6N__1__2O__2·H__2O__4S = 670.75 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,湿气 (吸湿),加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 188062-50-2 |
| Reaxys-RN | 10402665 |
| MDL编号 | MFCD04112763 |
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Specific rotation | -38.0 to -42.0 deg(C=0.5, methanol) |
| Water | max. 1.0 % |
| NMR | confirm to structure |
物性（参考值）
| 水溶性 | 可溶 |
| 在水中的溶解度 | 77,000 mg/l 25 °C |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. H341 : Suspected of causing genetic defects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2933.59-000 |
应用
Abacavir Sulfate: A Nucleoside Analog Reverse Transcriptase Inhibitor (RTI)
Abacavir sulfate (1592U89 sulfate), a sulfate salt form of abacavir [A2694], is a nucleoside reverse transcriptase inhibitor (RTI) that inhibits HIV-1 in vitro with a potency similar to that of zidovudine [A2052]. Abacavir is converted by cellular enzymes to the active metabolite, carbovir triphosphate (CBV-TP) which is an analogue of deoxyguanosine-5’-triphosphate (dGTP). CBV-TP is incorporated into the virus DNA strand in place of dGTP, and inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP. (The product is for research purpose only.)
References
- 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity
- Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89
- Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89
- Separation and characterization of forced degradation products of abacavir sulphate by LC–MS/MS
- Determination of 19 antiretroviral agents in pharmaceuticals or suspected products with two methods using high-performance liquid chromatography
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