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CAS RN: 24390-14-5 | 产品编码: D4116
Doxycycline Hyclate
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| 产品编码 | D4116 |
纯度/分析方法 
|
>97.0%(HPLC) |
| 分子式/分子量 | C__2__2H__2__4N__2O__8·^^1/__2C__2H__6O·HCl·^^1/__2H__2O = 512.94 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| CAS RN | 24390-14-5 |
| 相关CAS RN
|
10592-13-9&564-25-0 |
| PubChem物质ID | 172089114 |
| Merck Index (14) | 3440 |
| MDL编号 | MFCD07357237 |
技术规格
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Specific rotation [a]20/D | -100 to -107 deg(C=1, 0.01mol/L HCl(MeOH)) |
| Water | 1.4 to 2.8 % |
| Ethanol(NMR) | 4.3 to 6.0 % |
物性（参考值）
| 比旋光度 [α]D | -104° (C=1,0.01mol/L HCl(MeOH)) |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2941.30-000 |
应用
Studies on the Antibacterial Activity of Doxycycline
References
- Doxycycline revisited
- Development and evaluation of novel biodegradable microspheres based on poly(D,L-lactide-co-glycolide) and poly(ε-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: In vitro and in vivo studies
- Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis.
- Subantimicrobial dose doxycycline as an adjunct to scaling and root planing: Post-treatment effects
应用
Applications of Doxycycline to Biogenetics Studies
References
- Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
- Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity
- piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
- Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector
- Transcriptional activation by tetracyclines in mammalian cells
- M. Gossen, S. Freundlieb, G. Bender, G. Muller, W. Hillen, H. Bujard, Science 1995, 268, 1766.
参考文献
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