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CAS RN: 66335-38-4 | 产品编码: D4342
5'-Deoxy-5-fluorocytidine
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 203.0 to 210.0 °C |
物性（参考值）
| 熔点 | 204 °C |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
5'-Deoxy-5-Fluorocytidine: A Prodrug of Active Antitumor 5-FU
5'-Deoxy-5-fluorocytidine is a prodrug of active antitumor 5-FU [F0151] and an intermediary metabolite of capecitabine [C2878]. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine and doxifluridine [D3579], to form 5-FU. (The product is for research purpose only.)
References
- Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumors by enzymes concentrated in human liver and cancer tissue
- Clinical pharmacokinetics of capecitabine
- Identification of the cytosolic carboxylesterase catalyzing the 5'-deoxy-5-fluorocytidine formation from capecitabine in human liver
- Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide
- A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma
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