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CAS RN: 82159-09-9 | 产品编码: E0906
Epalrestat
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| 产品编码 | E0906 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__5H__1__3NO__3S__2 = 319.39 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 82159-09-9 |
| Reaxys-RN | 4236712 |
| PubChem物质ID | 172089065 |
| Merck Index (14) | 3605 |
| MDL编号 | MFCD00865484 |
技术规格
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 222.0 to 226.0 °C |
物性（参考值）
| 熔点 | 224 °C |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H300 : Fatal if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | XJ5131855 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | II |
| HS编码* | 2934.10-000 |
应用
Aldose Reductase (AR) Inhibitor
References
- Effects of a new aldose reductase inhibitor on various tissues in vitro
- H Terashima, K Hama, R Yamamoto, M Tsuboshima, R Kikkawa, I Hatanaka, Y Shigeta, J. Pharmacol. Exp. Ther. 1984, 229, 226.
- Epalrestat, an aldose reductase inhibitor, reduces the levels of Nepsilon-(carboxymethyl) lysine protein adducts and their precursors in erythrocytes from diabetic patients
- An aldose reductase inhibitor prevents glucose-induced increase in transforming growth factor-β and protein kinase C activity in cultured human mesangial cells
- Molecular modeling studies of the binding modes of aldose reductase inhibitors at the active site of human aldose reductase
- Aldose reductase structures: Implications for mechanism and inhibition
- Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy
- M. A. Ramirez, N. L. Borja, Pharmacotherapy 2008, 28, 646.
参考文献
技术文章
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技术规格
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