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CAS RN: 26116-56-3 | 产品编码: E1555
Erythromycylamine
纯度/分析方法: >90.0%(qNMR)
别名:
- 红霉胺
- (9S)-9-氨基-9-脱氧红霉素
- (9S)-脱氧红霉素
- (3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-10-氨基-6-[[(2S,3R,4S)-4-(二甲基氨基)-3-羟基-6-甲基四氢-2H-吡喃-2-基]氧基]-14-乙基-7,12,13-三羟基-4-[[(2R,4R,5S,6S)-5-羟基-4-甲氧基-4,6-二甲基四氢-2H-吡喃-2-基]氧基]-3,5,7,9,11,13-六甲基氧杂环十四烷-2-酮
- (9S)-9-Amino-9-deoxoerythromycin
- 9(S)-Erythromycylamine
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产品文档:
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This product has not been tested for potency and is guaranteed for chemical purity.
| 产品编码 | E1555 |
纯度/分析方法
|
>90.0%(qNMR) |
| 分子式/分子量 | C__3__7H__7__0N__2O__1__2 = 734.97 |
| 外观与形状(20°C) | 固体 |
储存温度
|
冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
包装和容器
|
200MG-Glass Bottle with Plastic Insert (查看图片) |
| CAS RN | 26116-56-3 |
| Reaxys-RN | 4241492 |
| MDL编号 | MFCD00872156 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(qNMR) | min. 90.0 % |
| Specific rotation | -45.0 to -49.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
物性(参考值)
| 熔点 | 129 °C |
| 在水中的溶解度 | 1.22 g/l 20 °C |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H318 : Causes serious eye damage. H410 : Very toxic to aquatic life with long lasting effects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P280 : Wear eye protection/ face protection. P391 : Collect spillage. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
相关法规
| RTECS# | KF4590000 |
运输信息
| UN编号 | UN3077 |
| 类别 | 9 |
| 包装类别 | III |
| HS编码* | 2941.50-000 |
应用
Erythromycylamine: An Active Metabolite of a Macrolide Antibiotic Dirithromycin
Erythromycylamine is the major active metabolite of dirithromycin [D5495], derived from a macrolide antibiotic erythromycin [E0751].1) Erythromycylamine has excellent activity against Campylobacter, a type of bacteria that can cause diarrheal disease.2) (The product is for research purpose only.)
References
- 1) Synthesis and antimicrobial evaluation of dirithromycin (ASE 136; LY237216), a new macrolide antibiotic derived from erythromycin
- 2) Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides
- 3) Quantitative determination of erythromycylamine in human plasma by liquid chromatography-mass spectrometry and its application in a bioequivalence study of dirithromycin
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