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CAS RN: 64048-12-0 | 产品编码: G0626
GANT 58
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纯度/分析方法: >93.0%(qNMR)
别名：
- 2,3,4,5-四(4-吡啶基)噻吩
- 4-[2,4,5-三(4-吡啶基)-3-噻吩基]吡啶
- 4,4',4'',4'''-(噻吩-2,3,4,5-四基)四吡啶
- 2,3,4,5-Tetra(4-pyridyl)thiophene
- 4-[2,4,5-Tri(4-pyridinyl)-3-thienyl]pyridine
- 4,4',4'',4'''-(Thiophene-2,3,4,5-tetrayl)tetrapyridine
产品文档：
| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 10MG |
S$273.00
|
18 | 20 | 下单后约2周内可以发货 |
|
| 产品编码 | G0626 |
纯度/分析方法 
|
>93.0%(qNMR) |
| 分子式/分子量 | C__2__4H__1__6N__4S = 392.48 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| CAS RN | 64048-12-0 |
| Reaxys-RN | 47834 |
| MDL编号 | MFCD01103196 |
技术规格
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 93.0 % |
| Melting point | 249.0 to 253.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 250 °C |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
GANT 58: A Hedgehog/GLI (Hh/GLI) Signaling Pathway Inhibitor (Antagonist)
Hedgehog (Hh) signaling, which plays a critical role in cell proliferation and survival, has also been implicated in cancer initiation and progression. Glioma-associated oncogene (GLI) is an important nuclear transcription factor in Hh signaling and tumorigenesis. GANT 58 inhibits the Hedgehog/GLI (Hh/GLI) signaling pathway and induces apoptosis in cancer cell lines. (The product is for research purpose only.)
References
- Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
- Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells
- Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened (a review)
- Current trends in Hedgehog signaling pathway inhibition by small molecules (a review)
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