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CAS RN: 54-92-2 | 产品编码: I0893
Iproniazid
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| 产品编码 | I0893 |
纯度/分析方法 
|
>96.0%(T)(HPLC) |
| 分子式/分子量 | C__9H__1__3N__3O = 179.22 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 54-92-2 |
| Reaxys-RN | 142700 |
| Merck Index (14) | 5078 |
| MDL编号 | MFCD00153819 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(Nonaqueous Titration) | min. 96.0 % |
| Melting point | 109.0 to 114.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 112 °C |
| 水溶性 | 可溶 |
| 溶解性（可溶于） | 醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | NS1925000 |
运输信息
| HS编码* | 2933.39-000 |
应用
Iproniazid: A Monoamine-Oxidase Inhibitor (MAOI)
Iproniazid is a monoamine-oxidase inhibitor (MAOI). Originally, it was intended for the treatment of tuberculosis. In 1952, its antidepressant properties were discovered. MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters. Iproniazid was then used as an antidepressant agent until it was found to cause liver damage in 1961. It is oxidized by cytochrome P-450 enzymes in liver microsomes to a highly toxic agent, isopropylhydrazine. (The product is for research purpose only.)
References
- Monoamine oxidase inhibitors. (a review)
- Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat
- The role of metabolism in the hepatotoxicity of isoniazid and iproniazid (a review)
- Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today (a review)
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