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CAS RN: 172152-36-2 | 产品编码: I1191
Ilaprazole
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 艾普拉唑
- 2-[[(4-甲氧基-3-甲基-2-吡啶基)甲基]亚磺酰基]-6-(1H-吡咯-1-基)-1H-苯并咪唑
- 2-[[(4-甲氧基-3-甲基吡啶-2-基)甲基]亚磺酰基]-6-(1H-吡咯-1-基)-1H-苯并[d]咪唑
- 2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-1H-benzimidazole
- 2-[[(4-Methoxy-3-methylpyridin-2-yl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole
产品文档：
| 产品编码 | I1191 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__9H__1__8N__4O__2S = 366.44 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 172152-36-2 |
| Reaxys-RN | 8859737 |
| MDL编号 | MFCD00942538 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 149.0 to 153.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 151 °C |
GHS
相关法规
运输信息
| HS编码* | 2933.39-000 |
应用
Ilaprazole: A Proton Pump Inhibitor with Superior Pharmacological Profile
Ilaprazole (IY-81149) is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD) and duodenal ulcer in clinical.1,2) Compared with all other PPIs, ilaprazole has shown an extended plasma half-life, a metabolism not significantly influenced by CYP2C19 genetic polymorphism and similar safety.2) Ilaprazole can be used with clarithromycin [C2220] and amoxicillin [A2099] as a triple therapy regimen for eradicating Helicobacter pylori.3) In addition, there are reports that PPIs including ilaprazole suppresses cancer growth.4) (The product is for research purpose only.)
References
- 1) General pharmacology of IY-81149, a new proton pump inhibitor
- 2) Ilaprazole for the treatment of gastro-esophageal reflux (a review)
- 3) Pharmacokinetic drug interaction and safety after coadministration of clarithromycin, amoxicillin, and ilaprazole: a randomised, open-label, one-way crossover, two parallel sequences study
- 4) Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase.
- 5) Determination of Proton Pump Inhibitors by Spectrophotometric, Chromatographic and by Hyphenated Techniques: A Review
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技术规格
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