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CAS RN: 1432597-26-6 | 产品编码: L0347
LDN-212854
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| 产品编码 | L0347 |
纯度/分析方法 
|
>95.0%(HPLC) |
| 分子式/分子量 | C__2__5H__2__2N__6 = 406.49 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| CAS RN | 1432597-26-6 |
| Reaxys-RN | 23637228 |
| MDL编号 | MFCD28099808 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Water | max. 13.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 216 °C(dec.) |
GHS
相关法规
运输信息
| HS编码* | 2933.59-000 |
应用
LDN-212854: A Selective Activin Receptor-Like Kinase-2 (ALK2) Inhibitor
LDN-212854 is a selective inhibitor of activin receptor-like kinase-2 (ALK2) which is a member of the type I BMP receptors. BMP plays a fundamental role in the regulation of bone organogenesis through the activation of receptor serine/threonine kinases, and BMP signaling regulates many different biological processes, including cell growth, differentiation, and embryogenesis.
References
- Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor
- Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe
- Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2
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