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CAS RN: 14417-88-0 | 产品编码: M3871
Melinamide
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| 产品编码 | M3871 |
纯度/分析方法 
|
>95.0%(GC) |
| 分子式/分子量 | C__2__6H__4__1NO = 383.62 |
| 外观与形状（20°C） | 液体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| CAS RN | 14417-88-0 |
| Reaxys-RN | 2950179 |
| MDL编号 | MFCD01716255 |
技术规格
| Appearance | Colorless to Light yellow clear liquid |
| Purity(GC) | min. 95.0 % |
| NMR | confirm to structure |
物性（参考值）
| 沸点 | 217 °C/0.05 mmHg |
GHS
相关法规
| RTECS# | OI9410000 |
运输信息
| HS编码* | 2924.29-000 |
应用
Melinamide: A Potent and Selective Inhibitor of ACAT
Melinamide is a potent and selective inhibitor of Acyl-Coenzyme A (ACAT, also known as sterol O-acyltransferase or SOAT), which is an intracellular enzyme that catalyzes the formation of cholesteryl esters from cholesterol and fatty acyl-CoA.1,2) Recently, many studies have suggested that ACAT-1 (SOAT-1) plays a critical role in cancer initiation and progression and is an attractive target for novel anticancer therapies.2,3) (The product is for research use only.)
References
- 1) Formation of fatty acid ethyl esters in rat liver microsomes
- 2) Targeting Sterol O-Acyltransferase/Acyl-CoA: Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential (a review)
- 3) Cholesterol metabolism: New functions and therapeutic approaches in cancer (a review)
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技术规格
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