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CAS RN: 13553-79-2 | 产品编码: R0200
Rifamycin S
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| 产品编码 | R0200 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__3__7H__4__5NO__1__2 = 695.76 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 13553-79-2 |
| Reaxys-RN | 604802 |
| PubChem物质ID | 354335535 |
| Merck Index (14) | 8217 |
| MDL编号 | MFCD06198807 |
技术规格
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 96.0 % |
| Specific rotation [a]20/D | +451 to +500 deg(C=0.1, methanol) |
物性（参考值）
| 熔点 | 201 °C |
| 比旋光度 [α]D | 476° (C=0.1,MeOH) |
| 最大吸收波长 | 390 nm (MeOH) |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H371 : May cause damage to organs. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P405 : Store locked up. |
相关法规
| RTECS# | KD1925000 |
运输信息
| HS编码* | 2941.90-000 |
应用
Rifamycin S: A "Classic" Rifamycin with Potent Antimicrobial Activity but Poor Tolerability
Rifamycin S belongs to the family of ansamycin antibiotics, rifamycins. Initially, rifamycins were discovered referred to as rifamycin A, B, C, D, E in 1957. Among these, rifamycin B isolated in a pure form. Although its antimicrobial activity was moderate, it was oxidized and hydrolyzed to yield the highly active rifamycin S, a quinone molecular with potent antimicrobial activity but poor tolerability. Rifamycins inhibit DNA-dependent RNA polymerase in susceptible strains of bacteria, including Mycobacterium tuberculosis and Gram-positive bacteria. The rifamycin group includes the "classic" rifamycins as well as active rifamycin derivatives, rifampicin [R0079], rifaximin [R0101] and rifabutin [R0211]. (The product is for research purpose only.)
References
- Correlation of structure and activity in ansamycins: structure, conformation, and interactions of antibiotic rifamycin S
- A comparative study of the redox-cycling of a quinone (rifamycin S) and a quinonimine (rifabutin) antibiotic by rat liver microsomes
- Rifamycin-Mode of Action, Resistance, and Biosynthesis (a review)
- Identification and quantitation of rifamycins by reversed-phase high-performance liquid chromatography
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