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CAS RN: 104-06-3 | 产品编码: T3632
Thiacetazone
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 250MG |
S$117.00
|
7 | 0 | 下单后约3-4周内可以发货 |
|
| 产品编码 | T3632 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__1__0H__1__2N__4OS = 236.29 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 104-06-3 |
| Reaxys-RN | 2810335 |
| PubChem物质ID | 354335296 |
| MDL编号 | MFCD00022157 |
技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 22.50 to 24.50 % |
物性（参考值）
| 熔点 | 223 °C |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | AE3850000 |
运输信息
| HS编码* | 2930.90-900 |
应用
Thiacetazone: A Bacteriostatic Antitubercular Agent
Thiacetazone has been used as an antitubercular agent since the 1960s. Reportedly, thiacetazone is a prodrug that is oxidatively converted to their active forms by the flavin monooxygenase EtaA of Mycobacterium tuberculosis. Thiacetazone is bacteriostatic in action against tuberculosis through the inhibition of mycolic acid biosynthesis. Because the activity of thiacetazone is weak, it is usually used as a combination with first-line tuberculosis medications, such as isoniazid [I0138] and rifampicin [R0079]. (The product is for research purpose only.)
References
- Oxidative Activation of Thiacetazone by the Mycobacterium tuberculosis Flavin Monooxygenase EtaA and Human FMO1 and FMO3
- A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone
- Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases (a review)
- Antituberculosis agents (a review)
- Isocratic high-performance liquid chromatographic determination of thiacetazone by direct injection of plasma into an internal surface reversed-phase column
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