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CAS RN: 2140-67-2 | 產品號碼: D6076
N,N-Dimethylguanosine
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| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 25MG |
NT$7,266
|
8 | 0 | 下單後約2週內可以出貨 |
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洽詢。
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| 產品號碼 | D6076 |
純度/分析方法 
|
>95.0%(HPLC) |
| 分子式 / 分子量 | C__1__2H__1__7N__5O__5 = 311.30 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| CAS RN | 2140-67-2 |
| Reaxys-RN | 47545 |
| MDL編號 | MFCD00057049 |
產品規格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Water | max. 1.0 % |
| Specific rotation | -33.0 to -37.0 deg(C=0.1, 1M NaOHaq.) |
| NMR | confirm to structure |
性質
| 熔點 | 239 °C(dec.) |
GHS
相關法規
運輸資料
| HS編碼* | 2934.99-000 |
Application
N,N-Dimethylguanosine: a modified ribonucleoside in tRNA and rRNA
N,N-Dimethylguanosine (N2,N2-dimethylguanosine, m22G) is a modified ribonucleoside that has long been known to present in tRNA and rRNA. Recent studies have discovered that N,N-dimethylguanosine is a prevalent RNA modification in eukaryotes and has roles in cell viability and development through these effects to RNA as follows; RNA stability and RNA structure.1-3) In addition, there are reports that the levels of modified nucleosides, including N,N-dimethylguanosine, have served as potential biomarkers for cancer and various diseases in many studies.4,5)
References
- Enzymic formation of N2,N2-dimethylguanosine in eukaryotic tRNA: importance of the tRNA architecture (a review)
- Location of N2,N2-dimethylguanosine-specific tRNA methyltransferase
- Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m22G: A pairs
- Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension
- A Fast Capillary Electrophoresis Method for Separation and Quantification of Modified Nucleosides in Urinary Samples
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