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CAS RN: 58546-54-6 | 產品號碼: G0537
Gomisin A
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純度/分析方法: >96.0%(HPLC)
别名:
- Schisandrol B
- Besigomsin
- (6S,7S)-1,2,3,13-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-6-ol
- (6S,7S,13aR)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol
文件：
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產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Melting point | 91.0 to 95.0 °C |
| Specific rotation [a]20/D | +67.0 to +73.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
性質
| 熔點 | 93 °C |
| 比旋光 [α]D | 70° (C=1,CHCl3) |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | DE8396900 |
運輸資料
| HS編碼* | 2932.99-000 |
Application
Gomisin A: A Lignan Contained in the Dried Fruits of Schizandra chinensis
Gomisin A (schisandrol B) is a lignan contained in the dried fruits of Schizandra chinensis (Schisandraceae) which is a traditional medicine used as an antitussive and a tonic.1,2) It has been reported that gomisin A possesses various pharmacological activities, such as anti-inflammatory, antihypertensive, neuroprotective, and anti-proliferation properties.3-5) In addition, gomisin A has protective activity against hepatic and renal injury induced by substances, such as acetaminophen and carbon tetrachloride.6,7) (The product is for research purpose only.)
References
- 1) The constituents of Schisandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin
- 2) A simple and sensitive HPLC method for the simultaneous determination of eight bioactive components and fingerprint analysis of Schisandra sphenanthera
- 3) Pharmacological studies on schizandra fruit. I. General pharmacological effects of gomisin A and schizandrin (in Japanese, its abstract in English.)
- 4) Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells
- 5) Gomisin A improves scopolamine-induced memory impairment in mice
- 6) Preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats
- 7) Pharmacological studies on schizandra fruits. II. Effects of constituents of shizandra fruits on chemical-induced hepatic damage in rats (in Japanese, its abstract in English.)
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