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CAS RN: 71-00-1 | 產品號碼: H0149
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Specific rotation [a]20/D | +12.0 to +14.0 deg(C=11, 6mol/L HCl) |
| Solubility in 1mol/L HCl | almost transparency |
性質
| 熔點 | 281 °C |
| 比旋光 [α]D | 13° (C=11,6mol/L HCl) |
GHS
相關法規
| RTECS # | MS3070000 |
運輸資料
| HS編碼* | 2933.29-000 |
Application
Bacterial spore germinant research
Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.1) Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”1) and have been evaluated the efficacy of germinant administration combined with antibiotics (for example, reports by N. Budi et al.2,3)). Cogerminants are compounds that do not have germination-stimulating activity in themselves but stimulate germination when combined with other compounds. L-Histidine has been reported to act as a cogerminant in combination with glycine (G0099) and Taurocholate (T0808) for Clostridium difficile spores.4)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Germinants and Their Receptors in Clostridia
- 2) Omadacycline Compared to Vancomycin When Combined with Germinants To Disrupt the Life Cycle of Clostridioides difficile.
- 3) Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model
- 4) Histidine acts as a co-germinant with glycine and taurocholate for Clostridium difficile spores
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