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CAS RN: 13860-38-3 | 產品號碼: M3387
1-Methylpseudouridine
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| 產品號碼 | M3387 |
純度/分析方法 
|
>99.0%(HPLC) |
| 分子式 / 分子量 | C__1__0H__1__4N__2O__6 = 258.23 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器
|
100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 13860-38-3 |
| Reaxys-RN | 551569 |
| MDL編號 | MFCD10687017 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 187.0 to 191.0 °C |
| Specific rotation | -6.0 to -8.0 deg (C=1, water) |
| NMR | confirm to structure |
性質
| 熔點 | 189 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2934.99-000 |
Application
1-Methylpseudouridine (m1Ψ): A Non-Natural Pyrimidine Nucleoside Found in mRNA Vaccines
In recent years, numerous studies have demonstrated the outstanding abilities of mRNA to elicit potent immune, making it a viable new platform for vaccine development1). Additionally there are reports on incorporation of modified nucleobases into mRNA offering advantages for the generation of potent and long-lived antibody responses. In protein biosynthesis, 1-methylpseudouridine (m1Ψ) and pseudouridine (Ψ) [P2939 (synthetic)] [P2396] are read like uridine (U) and enable comparatively high protein yields. Furthermore, m1Ψ enhances immune evasion, protein production, and consequently vaccine efficacy.2-4)
References
- 1) mRNA vaccine for cancer immunotherapy (a review)
- 2) N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
- 3) N1-methyl-pseudouridine in mRNA enhances translation through eIF2α dependent and independent mechanisms by increasing ribosome density
- 4) Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines (a review)
PubMed Literature
Please visit the Pubchem page at this link.
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