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CAS RN: 20244-86-4 | 產品號碼: M3465
7-Methylguanosine
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純度/分析方法: >85.0%(HPLC)(qNMR)
别名:
- 2-Amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium
- 2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium
文件：
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| 產品號碼 | M3465 |
純度/分析方法 
|
>85.0%(HPLC)(qNMR) |
| 分子式 / 分子量 | C__1__1H__1__5N__5O__5 = 297.27 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片）, 200MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 20244-86-4 |
| Reaxys-RN | 3631436 |
| MDL編號 | MFCD16661197 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 85.0 area% |
| Purity(qNMR) | min. 85.0 % |
| Water | max. 11.0 % |
| NMR | confirm to structure |
性質
GHS
相關法規
運輸資料
| HS編碼* | 2934.99-000 |
Application
RNA aptamer research
Reference
- In vitro selection of a 7-methyl-guanosine binding RNA that inhibits translation of capped mRNA molecules
Application
7-Methylguanosine (m7G): The 5' Terminal Cap Structure Present on Eukaryotic mRNA
7-Methylguanosine (m7G) is a purine base modified by the addition of a methyl group and closely resembles the 5' terminal cap structure present on eukaryotic mRNA. The 7-methylguanosine “cap’ is required for the translation of the majority of mRNAs, and it has also been reported to stabilize mRNA against attack by exonucleases and to promote transcription, splicing, polyadenylation and nuclear export of mRNA.1-3) Therefore, efficient mRNA capping enzymatic processes have been studied utilizing 7-methylguanosine.4) In addition, 7-methylguanosine cannot be re-phosphorylated and reused for de novo synthesis, and so is excreted by cells and can be detected in serum and urine. Therefore, it has been used as a biomarker for some types of cancer.5,6) (The product is for research purpose only.)
References
- 1) What messenger RNA capping tells us about eukaryotic evolution (a review)
- 2) Viral and cellular mRNA capping: Past and prospects (a review)
- 3) Regulation of mRNA cap methylation (a review)
- 4) Enzymatic Assays to Explore Viral mRNA Capping Machinery (a review)
- 5) Development and validation of a rapid LC-MS/MS method for determination of methylated nucleosides and nucleobases in urine
- 6) Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers (a review)
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