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CAS RN: 187227-45-8 | 產品號碼: O0663
Oseltamivir Acid
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| 產品號碼 | O0663 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__4H__2__4N__2O__4 = 284.36 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器
|
100MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 187227-45-8 |
| Reaxys-RN | 7714446 |
| MDL編號 | MFCD00953940 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation | -24.0 to -30.0 deg(C=0.5, water) |
| Water | max. 5.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 187 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2924.29-000 |
Application
Oseltamivir Acid: An Active Metabolite of Oseltamivir
Oseltamivir acid (GS 4071, Ro 64-0802) is an active metabolite of oseltamivir [O0591], which is a selective inhibitor of influenza virus neuraminidase that interferes with the release of viral particles from infected host cells. Oseltamivir is rapidly converted by hepatic esterases to the active metabolite, oseltamivir acid. It has high bioavailability and penetrates sites of infection at concentrations sufficient to inhibit viral replication. (The product is for research use only.)
References
- Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071
- Development of a high-performance liquid chromatographic-mass spectrometric assay for the specific and sensitive quantification of Ro 64-0802, an anti-influenza drug, and its pro-drug, oseltamivir, in human and animal plasma and urine
- Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations (a review)
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